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Updated: Jul 14, 2026
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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
High-mobility group box 1 protein plasma concentrations during septic shock.
Sébastien Gibot1, Frédéric Massin, Aurélie Cravoisy
1Hôpital Central, Service de Réanimation Médicale, 29 avenue du Maréchal de Lattre de Tassigny, 54000, Nancy, France. s.gibot@chu-nancy.fr
Intensive Care Medicine
|May 26, 2007
Summary
Plasma high-mobility group box 1 protein (HMGB1) levels correlate with organ dysfunction in septic shock. Elevated HMGB1 on day 3 predicts mortality, aiding in patient outcome assessment.
Area of Science:
- Critical Care Medicine
- Biomarkers
- Sepsis Research
Background:
- Sepsis remains a leading cause of mortality in intensive care units.
- Identifying reliable biomarkers for predicting outcomes in septic shock is crucial.
- High-mobility group box 1 protein (HMGB1) is implicated in inflammatory responses during sepsis.
Purpose of the Study:
- To determine plasma HMGB1 concentrations in septic shock patients.
- To explore the relationship between HMGB1 levels and organ dysfunction.
- To assess HMGB1's predictive value for patient outcomes in septic shock.
Main Methods:
- Prospective study of 42 critically ill septic shock patients.
- Plasma HMGB1 measured by ELISA at admission and on days 3, 7, and 14.
- Correlation analysis with SOFA score, lactate, and procalcitonin.
Main Results:
- Median admission HMGB1 was 4.4 ng/ml, not differing between survivors and nonsurvivors.
- HMGB1 positively correlated with SOFA score, lactate, and procalcitonin.
- On day 3, HMGB1 > 4 ng/ml predicted death (OR 5.5) and differentiated survivors from nonsurvivors (66% sensitivity, 67% specificity).
Conclusions:
- Plasma HMGB1 concentration is associated with organ dysfunction markers in septic shock.
- Day 3 HMGB1 levels can serve as a prognostic biomarker for mortality in septic shock patients.
- HMGB1 warrants further investigation as a therapeutic target in sepsis.
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