Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Social Anxiety Disorder01:28

Social Anxiety Disorder

Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive Detection of Acute Hyperglycemia Using Signal from Wearable ECG Sensors Considering Individual HRV Response Delays to Glucose.

Biosensors·2026
Same author

Erratum: A review of clinical pharmacology considerations in antibody-drug conjugates approved by the US Food and Drug Administration between 2000 and 2025.

Translational and clinical pharmacology·2026
Same author

Supercapacitive Carbon-Coated δ-MnO<sub>2</sub> Nanosheets as a Solid-Contact Material for Self-Testing Potassium-Ion Biosensors.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

<i>Aster yomena</i> Alleviates Chronic Unpredictable Mild Stress (CUMS)-Induced Depressive Cognitive Dysfunction by Regulating the HPA Axis and TLR4/NF-κB Pathway.

Journal of microbiology and biotechnology·2026
Same author

Cerebral blood flow estimation using NIRS in cardiac arrest patients: correlation with ROSC outcomes.

Resuscitation·2026
Same author

A review of clinical pharmacology considerations in antibody-drug conjugates approved by the US Food and Drug Administration between 2000 and 2025.

Translational and clinical pharmacology·2026

Related Experiment Video

Updated: Jul 14, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Cortical thinning in obsessive compulsive disorder.

Yong-Wook Shin1, So Young Yoo, Jun Ki Lee

  • 1Clinical Cognitive Neuroscience Center, SNU-MRC, Seoul, Korea.

Human Brain Mapping
|May 26, 2007
PubMed
Summary

Obsessive-compulsive disorder (OCD) patients exhibit significant cortical thinning in multiple brain regions, particularly within the left ventral cortex. This finding offers new insights into the neurobiological underpinnings of OCD.

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Related Experiment Videos

Last Updated: Jul 14, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Previous research suggests frontal-subcortical circuitry abnormalities in obsessive-compulsive disorder (OCD).
  • Evidence for structural abnormalities in these areas remains inconsistent.
  • Advances in neuroimaging allow for precise measurement of cortical thickness.

Purpose of the Study:

  • To investigate structural brain abnormalities in patients with OCD using cortical thickness measurements.
  • To identify specific regions of cortical thinning associated with OCD.
  • To explore the role of the ventral cortical system in OCD pathophysiology.

Main Methods:

  • Utilized the constrained Laplacian-based automated segmentation with proximities (CLASP) algorithm.
  • Measured cortical thickness in 55 patients with OCD and 52 healthy controls.
  • Compared cortical thickness between OCD patients and the control group.

Main Results:

  • Obsessive-compulsive disorder patients showed significantly thinner cortices in multiple brain regions compared to controls.
  • Specifically, thinner cortices were observed in the left inferior frontal, middle frontal, precentral, superior temporal, parahippocampal, orbitofrontal, and lingual areas.
  • The majority of these thinned regions were located within the left ventral cortex.

Conclusions:

  • Cortical thinning in specific left-sided ventral regions is a prominent feature in patients with obsessive-compulsive disorder.
  • These findings suggest that the left ventral cortical system may play a crucial role in the pathophysiology of OCD.
  • This study provides novel neuroimaging evidence contributing to our understanding of OCD's structural brain alterations.