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Updated: Jul 14, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

[In case of risks and side effects: ask your genes, too]

Annemarie Möritz1

  • 1a.th.moeritz@t-online.de

Medizinische Monatsschrift Fur Pharmazeuten
|May 29, 2007
PubMed

Insights

Adverse drug reactions cause 5-17% of hospitalizations, influenced by genetics. Despite intensive research into pharmacogenetics, few diagnostic tests are available for these genetic factors.

Area of Science:

  • Pharmacogenetics
  • Clinical Pharmacology
  • Drug Interactions

Context:

  • 5-17% of hospitalizations stem from adverse drug reactions or interactions.
  • Both genetic and non-genetic factors contribute to these drug-related issues.
  • Genetic influences on drug response are a significant area of research.

Purpose:

  • To highlight the prevalence of adverse drug events.
  • To underscore the role of genetic factors in drug response.
  • To point out the limited availability of genetic diagnostic tests.

Summary:

  • Adverse drug reactions and interactions are a substantial cause of hospitalizations, accounting for 5-17% of admissions.
  • Genetic variations play a crucial role in how individuals respond to medications, influencing drug efficacy and toxicity.
  • Despite extensive research in pharmacogenetics, the clinical application of genetic testing for drug response remains limited, with only one commercial test available for two genes.

Impact:

  • Increases awareness of the clinical significance of adverse drug events.
  • Emphasizes the need for further development and accessibility of pharmacogenetic testing.
  • Could inform clinical practice and personalized medicine approaches to drug therapy.

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