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Functional sequestration of transcription factor activity by repetitive DNA

Xiaowei Liu1, Bo Wu, Jaroslaw Szary

  • 1Diabetes Center and Department of Medicine, University of California, San Francisco, California 94143, USA.

The Journal of Biological Chemistry
|May 29, 2007
PubMed
Summary

Repetitive DNA can bind transcription factors like CCAAT/enhancer-binding protein alpha (C/EBPalpha), sequestering it in heterochromatin. This binding reduces available C/EBPalpha for gene regulation, impacting transcription output.

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