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Conservation of Protein Domains

Conservation of Protein Domains

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jul 14, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

ProtSweep, 2Dsweep and DomainSweep: protein analysis suite at DKFZ.

C del Val¹, P Ernst, M Falkenhahn

¹DKFZ, German Cancer Research Center, Division of Molecular Biophysics, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. c.delval@dkfz.de

Nucleic Acids Research

|May 29, 2007

Summary

We developed automated protein annotation pipelines (ProtSweep, DomainSweep, 2Dsweep) to simplify complex bioinformatics tasks. These tools offer exhaustive structural and functional analysis using updated databases for researchers.

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Last Updated: Jul 14, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Mapping Dysfunctional Protein-Protein Interactions in Disease

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Published on: October 24, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

Numerous bioinformatics software services are publicly available, but their discovery and integration are challenging for users.
Navigating diverse web services for transcript information analysis is time-consuming and resource-intensive, particularly for non-experts.

Purpose of the Study:

To automate protein annotation by homology (ProtSweep), domain analysis (DomainSweep), and secondary structure element analysis (2Dsweep).
To provide an exhaustive structural and functional analysis of proteins using integrated bioinformatics tools.

Main Methods:

Development of a suite of automated protein annotation pipelines (ProtSweep, DomainSweep, 2Dsweep).
Integration of multiple analysis methods with up-to-date public databases.
Orientation towards homology, domain, and secondary structure element analysis.

Main Results:

Successful development of three distinct protein annotation pipelines.
Enabling exhaustive structural and functional protein analysis through automated workflows.
Providing accessible bioinformatics tools for academic users.

Conclusions:

The developed protein annotation pipelines streamline complex bioinformatics analyses.
These automated tools facilitate comprehensive protein analysis for researchers.
The ProtSweep, DomainSweep, and 2Dsweep servers offer valuable resources for the scientific community.