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Related Experiment Videos

Inadequate parathyroid response in acute pancreatitis.

G M Robertson, E W Moore, D M Switz

    The New England Journal of Medicine
    |March 4, 1976
    PubMed
    Summary

    Hypocalcemia in acute pancreatitis may stem from relative parathyroid insufficiency, not glucagon or calcitonin. Patients

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    Area of Science:

    • Endocrinology
    • Gastroenterology

    Background:

    • Hypocalcemia is a common complication in acute pancreatitis.
    • The underlying mechanisms are not fully understood.

    Purpose of the Study:

    • To investigate the causes of hypocalcemia in patients with acute pancreatitis.
    • To determine the roles of parathyroid hormone, calcitonin, and glucagon in this condition.

    Main Methods:

    • Studied nine consecutive hypocalcemic patients with acute pancreatitis.
    • Measured serum ionized calcium, parathyroid hormone, calcitonin, and glucagon levels.
    • Administered parenteral parathyroid extract and glucagon to assess responses.

    Main Results:

    • Patients exhibited significantly low serum ionized calcium levels (mean 0.97 mM).
    • Parathyroid hormone levels were normal in most patients, but they responded to parathyroid extract.
    • Calcitonin and glucagon levels were elevated in some patients but did not correlate with calcium levels or respond to glucagon administration.

    Conclusions:

    • Glucagon and calcitonin are unlikely to be the primary causes of hypocalcemia in acute pancreatitis.
    • The findings suggest relative parathyroid insufficiency contributes to persistent hypocalcemia in these patients.

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