Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal developmental changes in inner ear ornithine decarboxylase (ODC).

C M Henley1

  • 1Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030.

Hearing Research
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distortion product otoacoustic emissions and outer hair cell defects in the hyt/hyt mutant mouse.

Hearing research·1999
Same author

Increased susceptibility of male rats to kanamycin-induced cochleotoxicity.

Hearing research·1999
Same author

Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse.

Genomics·1998
Same author

Effects of anesthesia on polyamine metabolism and water content in the rat brain.

Journal of neurotrauma·1998
Same author

Quantification of furosemide from serum and tissues using high-performance liquid chromatography.

Journal of chromatography. B, Biomedical sciences and applications·1997
Same author

S-adenosylmethionine decarboxylase activity is decreased in the rat cortex after traumatic brain injury.

Journal of neurochemistry·1997

Ornithine decarboxylase (ODC) levels rise significantly during early rat cochlear development, peaking around day 10. This pattern correlates with hearing maturation and increased susceptibility to aminoglycoside ototoxicity.

Area of Science:

  • Oto-pharmacology
  • Developmental biology
  • Molecular biology

Background:

  • Ornithine decarboxylase (ODC) is crucial for polyamine synthesis, impacting cellular growth and differentiation.
  • ODC has been quantified in adult rat cochlear tissue, but not during inner ear development.

Purpose of the Study:

  • To quantitatively assess ODC levels in rat cochlear tissues during the critical period of hearing development.

Main Methods:

  • Quantitative measurement of ODC in cochlear tissues of developing rats.
  • Comparison of ODC levels across different cochlear structures (lateral wall, organ of Corti, cochlear nerve).

Main Results:

  • Cochlear ODC levels were significantly elevated during cochlear maturation, increasing rapidly in the first 10 days and peaking on day 10.

Related Experiment Videos

  • ODC levels were higher in the lateral wall/organ of Corti compared to the cochlear nerve in developing rats.
  • ODC activity was highest in the organ of Corti in 10-day-old rats.

    • Conclusions:

    • Postnatal changes in ODC activity mirror the functional maturation of hearing and the heightened sensitivity to aminoglycoside ototoxicity in developing rats.
    • Aminoglycoside inhibition of ODC and subsequent polyamine synthesis may explain the ototoxicity observed in developing animals.