Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaine-induced psychosis.

K T Brady1, R B Lydiard, R Malcolm

  • 1Department of Psychiatry, Medical University of South Carolina, Charleston 29425.

The Journal of Clinical Psychiatry
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comorbid anxiety disorders and baseline medication regimens predict clinical outcomes in individuals with co-occurring bipolar disorder and alcohol dependence: Results of a randomized controlled trial.

Psychiatry research·2020
Same author

Prescription Drug Monitoring Program Use: National Dental PBRN Results.

JDR clinical and translational research·2019
Same author

Effects of yohimbine and drug cues on impulsivity and attention in cocaine-dependent men and women and sex-matched controls.

Drug and alcohol dependence·2016
Same author

From the benches to the trenches : training residents to provide emergency outreach services-a public/academic project.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
Same author

Efficacy and tolerability of long-term venlafaxine XR therapy for GAD. Results of long-term, double-blind, placebo-controlled studies.

Postgraduate medicine·2009
Same author

Novel treatments for major depressive disorder.

CNS spectrums·2009
Same journal

Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

The Journal of clinical psychiatry·2026
Same journal

Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

The Journal of clinical psychiatry·2026
Same journal

Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

The Journal of clinical psychiatry·2026
Same journal

Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

The Journal of clinical psychiatry·2026
Same journal

Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

The Journal of clinical psychiatry·2026
Same journal

The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

The Journal of clinical psychiatry·2026
See all related articles

Cocaine-induced psychosis is common in chronic users, with paranoia and hallucinations frequently reported. Greater duration and amount of cocaine use, along with male sex, increase the risk of developing this condition.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Medicine

Background:

  • Chronic stimulant use can induce paranoid psychosis, mimicking schizophrenia.
  • While studied in amphetamine users, cocaine-induced psychosis remains less explored systematically.

Purpose of the Study:

  • To systematically evaluate the experience of psychosis in individuals dependent on cocaine.
  • To identify factors associated with the development of cocaine-induced psychosis.

Main Methods:

  • A standardized, semistructured interview was used to assess psychosis experiences in 55 individuals admitted for cocaine dependence treatment.
  • Data collected included lifetime and recent cocaine use patterns, duration of use, and demographic information.

Main Results:

Related Experiment Videos

  • Over half (53%) of subjects reported transient cocaine-induced psychosis.
  • Increased cocaine use in the year prior to admission and longer duration of use were significantly associated with psychosis.
  • Males were more likely to develop psychosis, and symptoms included paranoid delusions and various hallucinations (auditory, visual, tactile).

Conclusions:

  • Cocaine-induced paranoia is a frequent occurrence in chronic users.
  • The amount and duration of cocaine use are significant risk factors for developing psychosis.
  • Findings support implications for a kindling model of cocaine-induced psychosis.