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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Published on: September 7, 2022

Serologic evidence for regional differences in pediatric cryptococcal infection.

Jennifer Davis1, Wang Yong Zheng, Aharona Glatman-Freedman

  • 1Department of Pediatrics, Childrens Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

The Pediatric Infectious Disease Journal
|May 29, 2007
PubMed
Summary

Unrecognized cryptococcal infections are common in immunocompetent children in the Bronx, but rare in Dutchess County and the Philippines. This study used serology to estimate the prevalence of these common fungal infections.

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06:03

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Published on: September 20, 2024

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Cryptococcus neoformans is a fungus found in pigeon droppings.
  • Subclinical cryptococcal infections are hypothesized to be common in healthy individuals.
  • Serological studies are crucial for understanding infection prevalence.

Purpose of the Study:

  • To estimate the prevalence of unrecognized cryptococcal infections.
  • To compare infection rates in immunocompetent children across different geographic regions.
  • To investigate the epidemiology of Cryptococcus neoformans in children.

Main Methods:

  • Utilized serological testing to detect antibodies against Cryptococcus neoformans.
  • Collected samples from immunocompetent children in three distinct regions: Bronx, Dutchess County (NY), and the Philippines.
  • Analyzed serological data to determine infection prevalence.

Main Results:

  • High prevalence of unrecognized cryptococcal infections observed in children from the Bronx.
  • Low prevalence of cryptococcal infections found in children from Dutchess County, NY.
  • Minimal cryptococcal infection rates reported in children from the Philippines.

Conclusions:

  • Unrecognized cryptococcal infections are highly prevalent in specific urban environments like the Bronx.
  • Geographic location significantly impacts the prevalence of cryptococcal infections in children.
  • Further research is needed to understand the factors contributing to these regional differences.