Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic cycling to decrease bacterial antibiotic resistance: a 5-year experience on a bone marrow transplant unit.

J Cadena1, C A Taboada, D S Burgess

  • 1Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. cadenazuluag@uthscsa.edu

Bone Marrow Transplantation
|May 29, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of HPV-Associated Oropharyngeal Squamous Cell Carcinoma with Block-Like, Partial Loss of p16 Expression.

Head and neck pathology·2022
Same author

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Breast ductal carcinoma in situ with micro-invasion versus ductal carcinoma in situ: a comparative analysis of clinicopathological and mammographic findings.

Clinical radiology·2021
Same author

[Prospective randomized controlled study on clinical effects of autologous skin paste in repairing medium-thickness skin donor site wounds].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2021
Same author

[Effect of autologous skin paste on repairing wound of donor site of medium-thickness skin graft].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2021
Same author

Unconventional Transverse Transport above and below the Magnetic Transition Temperature in Weyl Semimetal EuCd_{2}As_{2}.

Physical review letters·2021
Same journal

CHIME: a novel HLA eplet model associates with non-relapse mortality in haploidentical hematopoietic cell transplant with post-transplant cyclophosphamide.

Bone marrow transplantation·2026
Same journal

Transplant outcomes for patients with severe acquired aplastic anemia over the age of 40 using busulfan, fludarabine, reduced-dose cyclophosphamide, and anti-thymocyte globulin conditioning regimen.

Bone marrow transplantation·2026
Same journal

A holistic prognostic model for leukemia-free survival after allogeneic transplantation in acute leukemia.

Bone marrow transplantation·2026
Same journal

Early software-assisted response predicts survival in a prospective cohort of 258 newly diagnosed cGvHD patients.

Bone marrow transplantation·2026
Same journal

Evaluation of a novel eHealth-facilitated, post HCT-integrated care model on implementation and rehospitalization: results from the Swiss SMILe hybrid-RCT.

Bone marrow transplantation·2026
Same journal

Impact of doublet post-transplant maintenance on outcomes in multiple myeloma: A propensity score matching analysis.

Bone marrow transplantation·2026
See all related articles

Antibiotic cycling in a hematology-oncology unit preserved Gram-negative susceptibility but increased Enterococcus resistance. This strategy impacts antimicrobial resistance patterns, necessitating careful monitoring of specific pathogens.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Oncology

Background:

  • Multidrug-resistant pathogens pose significant clinical challenges.
  • Antimicrobial resistance necessitates strategies like antibiotic cycling.
  • Limited research exists on antibiotic cycling in hematology-oncology settings.

Purpose of the Study:

  • To evaluate the impact of antibiotic cycling on antimicrobial resistance in a hematology-oncology unit.
  • To compare resistance patterns before and after intervention, and with a solid organ transplant ICU.

Main Methods:

  • Implemented antibiotic cycling (piperacillin-tazobactam and cefepime) from January 1999 to June 2004.
  • Compared clinical isolates' susceptibility in pre- and post-intervention periods.
  • Benchmarked against isolates from a solid organ transplant intensive care unit (TICU).

Related Experiment Videos

Main Results:

  • Gram-negative isolate rates remained stable.
  • Susceptibility to cefepime and piperacillin-tazobactam among Gram-negatives was maintained.
  • Observed an increase in Enterococcus spp. with decreased susceptibility to ampicillin and vancomycin.

Conclusions:

  • Antibiotic cycling preserved Gram-negative susceptibility in this hematology-oncology unit.
  • The strategy was associated with an increase in Enterococcus spp. and resistance to ampicillin and vancomycin.
  • Careful monitoring is needed to manage emerging resistance patterns during antibiotic cycling.