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Perfusion-sensitive MRI of pilocytic astrocytomas: initial results
Sylvie D Grand1, Stéphane Kremer, Irène M Tropres
1Neuroradiology, Hôpital Michallon, Grenoble, France. SGrand@chu-grenoble.fr
Neuroradiology
|May 29, 2007
Summary
Pilocytic astrocytomas (PA) typically show low relative cerebral blood volume (rCBV) and a specific signal intensity curve. These perfusion MRI findings aid in identifying these rare brain tumors.
Area of Science:
- Neuroradiology
- Neuro-oncology
- Medical Imaging
Background:
- Pilocytic astrocytomas (PA) are rare pediatric brain tumors.
- Accurate identification of PA is crucial for appropriate management.
- Perfusion MRI offers functional insights into tumor vascularity.
Purpose of the Study:
- To present imaging and perfusion data from nine patients with pilocytic astrocytomas.
- To discuss the functional characteristics of perfusion MRI in PA.
- To correlate perfusion findings with histopathological features.
Main Methods:
- Conventional and perfusion MRI were performed on nine pathologically confirmed PA patients.
- Relative cerebral blood volume (rCBV) was quantified within tumor areas.
- Maximum rCBV ratios were identified and compared to pathology.
Main Results:
- All patients demonstrated low rCBV values (mean 1, <1.5).
- The signal intensity curve exhibited a characteristic overshoot of the baseline.
- Perfusion parameters were analyzed in relation to tumor histology.
Conclusions:
- Pilocytic astrocytomas typically present with low rCBV.
- A distinct first-pass signal intensity curve crossing the baseline is characteristic of PA.
- These perfusion MRI features are valuable for diagnosing rare pilocytic astrocytomas.
