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Surgical intervention in children with Crohn's disease
R Leonor1, K Jacobson, V Pinsk
1Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
International Journal of Colorectal Disease
|May 29, 2007
Summary
Pediatric Crohn's disease patients not treated with immunomodulator therapy had increased surgery rates. Extensive small intestinal involvement in pediatric Crohn's disease patients was associated with a lower likelihood of surgery.
Area of Science:
- Pediatric Gastroenterology
- Inflammatory Bowel Disease Research
- Surgical Outcomes in Children
Background:
- Crohn's disease (CD) is a chronic gastrointestinal inflammatory condition requiring extensive treatment.
- Two-thirds of CD patients undergo surgery in their lifetime.
- This study focuses on pediatric CD patients at British Columbia Children's Hospital.
Purpose of the Study:
- To review demographics and treatments of pediatric CD patients.
- To assess factors influencing surgical intervention in pediatric CD.
- To compare surgical and non-surgical patient groups.
Main Methods:
- Retrospective review of 280 pediatric CD patients diagnosed between 1994-2003.
- Data collected included demographics, symptom duration, treatments, and surgical parameters.
- Comparison of operative vs. non-operative groups regarding disease involvement, treatment, and complications.
Main Results:
- 19.6% of pediatric CD patients underwent surgery.
- Lack of immunomodulator therapy significantly increased surgery odds (OR 1.95).
- Extensive small intestinal involvement decreased surgery likelihood (OR 0.386).
Conclusions:
- Immunomodulator therapy is associated with reduced surgical incidence in pediatric CD.
- Pediatric CD patients with extensive small intestinal disease are less likely to require surgery during childhood.
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