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Migraine in multiple sclerosis.

Debra G Elliott¹

¹Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA.

International Review of Neurobiology

|May 29, 2007

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Headache and migraine are common in multiple sclerosis (MS), potentially leading to misdiagnosis and diagnostic confusion due to overlapping symptoms and MRI findings. Awareness of these headaches is key for effective management in MS patients.

Area of Science:

Neurology
Neuroimmunology

Background:

Headache and migraine are frequent in multiple sclerosis (MS).
Symptom overlap between migraine and MS-related headaches can cause misdiagnosis.
MRI findings in migraineurs may mimic MS lesions, causing confusion and anxiety.

Purpose of the Study:

To highlight the diagnostic challenges posed by headache and migraine in multiple sclerosis patients.
To discuss the potential pathophysiological links and management considerations for comorbid headaches in MS.

Main Methods:

Literature review and synthesis of existing studies on headache, migraine, and multiple sclerosis.
Analysis of diagnostic similarities and potential pathophysiological connections.

Main Results:

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Headache and migraine significantly impact MS diagnosis, radiological assessment, treatment, and quality of life.
Diagnostic confusion arises from symptom overlap and similar MRI findings.
Pathophysiology remains unclear, with brainstem lesions and inflammation proposed.
Management of new or treatment-induced headaches in MS is manageable with physician awareness.

Conclusions:

Headache and migraine are critical considerations in the comprehensive care of multiple sclerosis patients.
Early recognition and understanding of headache presentations in MS are essential for accurate diagnosis and treatment.
Further research into the shared pathophysiology may improve patient outcomes.