Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pain01:20

Pain

1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
Multiple Allele Traits01:49

Multiple Allele Traits

38.2K
The Concept of Multiple Allelism
38.2K
Multiple Regression01:25

Multiple Regression

4.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.8K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.8K
Multiple Voltage Sources01:25

Multiple Voltage Sources

1.8K
Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

488
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
488

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strengthened through Diversity: A Blueprint for Organizational Change.

Annals of neurology·2021
Same author

Safety, tolerability, and pharmacokinetics of weight-based IV loading dose of lacosamide in the ICU.

Epilepsy & behavior : E&B·2020
Same author

Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine.

Epilepsy & behavior : E&B·2020
Same author

Clinically presenting acute/subacute ischemic stroke: differential diagnosis of the non-enhanced CT hypodensity by advanced neuroimaging.

Neurological research·2009
Same author

Subcortical ischemic cerebrovascular dementia.

International review of neurobiology·2009
Same author

CNS germinoma of the pituitary and pineal regions, lateral ventricle, and fourth ventricle presenting in adulthood.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·2009

Related Experiment Video

Updated: Feb 11, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K

Multiple sclerosis as a painful disease.

Meghan Kenner1, Uma Menon, Debra G Elliott

  • 1Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA.

International Review of Neurobiology
|May 29, 2007
PubMed
Summary
This summary is machine-generated.

Pain is a common symptom in multiple sclerosis (MS), stemming from central or peripheral issues. Current treatments include medications and non-pharmacological methods, with emerging research in cannabis-based therapies.

More Related Videos

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.8K

Related Experiment Videos

Last Updated: Feb 11, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.8K

Area of Science:

  • Neurology
  • Pain Medicine
  • Immunology

Background:

  • Pain is a frequent and debilitating symptom for individuals with multiple sclerosis (MS).
  • Pain in MS can arise from central neuropathic or peripheral somatic pathology, and may be an initial presentation or herald an exacerbation.
  • Chronic pain can develop as a sequela of MS-related nerve damage, affecting pathways like the trigeminal nerve or central sensory structures.

Purpose of the Study:

  • To review the diverse causes and pathophysiology of pain in multiple sclerosis.
  • To outline current therapeutic strategies for managing pain in MS patients.
  • To highlight emerging research directions for novel pain treatments in MS.

Main Methods:

  • Literature review of studies on pain in multiple sclerosis.
  • Analysis of the pathophysiology linking MS lesions to pain mechanisms.
  • Summary of current pharmacological and non-pharmacological treatment modalities.

Main Results:

  • Pain in MS involves central/neuropathic or peripheral/somatic origins, with specific presentations like trigeminal neuralgia and Lhermitte's sign.
  • Pathophysiology may involve disrupted sensory pathways, abnormal nerve impulses, acquired channelopathies, or glial inflammatory mechanisms.
  • Current treatments include antiepileptics, muscle relaxants, anti-inflammatories, and non-pharmacological approaches.

Conclusions:

  • Pain management in MS is complex, requiring a multi-faceted approach.
  • Cannabis-based treatments show promise, warranting further investigation.
  • Targeting glial cell involvement presents a potential avenue for future therapeutic development.