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Related Experiment Videos

Ripply2 is essential for precise somite formation during mouse early development.

Techuan Chan1, Akiko Kondow, Akihiro Hosoya

  • 1ICORP Organ Regeneration Project, Japan Science and Technology Agency, 3-8-1 Komaba, Tokyo, Japan.

FEBS Letters
|May 29, 2007
PubMed
Summary
This summary is machine-generated.

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Ripply2 is crucial for proper skeletal development and somite segmentation. Knocking out Ripply2 in mice disrupted axial skeleton segmentation and gene expression, highlighting its role in embryonic development.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Ripply1 and Ripply2 are transcriptional corepressors with overlapping expression in the presomitic mesoderm during somitogenesis.
  • Ripply1 is essential for somite segmentation in zebrafish, but Ripply2's function is not well-defined.

Purpose of the Study:

  • To investigate the developmental role of Ripply2 by generating Ripply2 knock-out mice.

Main Methods:

  • Generation of Ripply2 knock-out mouse models.
  • Analysis of skeletal and somite segmentation defects.
  • Examination of gene expression patterns, including Notch2 and Uncx4.1.

Main Results:

  • Homozygous Ripply2 mutant mice exhibited defects in axial skeleton segmentation.

Related Experiment Videos

  • Somite segmentation was disrupted in Ripply2 knock-out mice.
  • Expression of Notch2 and Uncx4.1 was altered in the mutant mice.

    • Conclusions:

    • Ripply2 plays a significant role in the segmentation of the axial skeleton.
    • Ripply2 is involved in the process of somite segmentation.
    • Ripply2 contributes to the establishment of rostrocaudal polarity during embryonic development.