Roles for VEGF in the adult

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Updated: Jul 14, 2026

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

Arindel S R Maharaj1, Patricia A D'Amore

  • 1Schepens Eye Research Institute, 20 Staniford St., Boston, MA 02114, USA.

Microvascular Research
|May 29, 2007
PubMed

Insights

Vascular Endothelial Growth Factor (VEGF) plays a crucial role in maintaining adult tissues, not just during development or disease. Understanding its function in quiescent vasculature is key to improving therapies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Vascular Endothelial Growth Factor (VEGF) is well-characterized in development and pathology.
  • Its function in normal adult tissues, particularly quiescent vasculature, remains poorly understood.
  • Adverse effects of anti-VEGF therapies hint at its role in healthy adult tissues.

Purpose of the Study:

  • To elucidate the function of VEGF in normal adult tissues.
  • To investigate VEGF's role in maintaining quiescent vasculature.
  • To differentiate VEGF's function as a maintenance versus angiogenic factor.

Main Methods:

  • Analysis of VEGF and its receptor expression in adult tissues.
  • Review of studies on the disease preeclampsia.
  • Experimental VEGF neutralization studies.

Main Results:

  • VEGF appears involved in endothelial cell survival and fenestration.
  • VEGF signaling and maintenance of non-endothelial cells are suggested.
  • Biochemical properties and interactions with other growth factors influence VEGF function.

Conclusions:

  • VEGF has a significant role in maintaining normal adult tissues.
  • Further understanding of adult VEGF function can optimize pro- and anti-angiogenic therapies.
  • Targeting VEGF requires careful consideration of its dual roles.

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