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Updated: Jul 14, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Genital human papilloma virus infection in mentally-institutionalized virgins
Takako Shimada1, Masako Miyashita, Shoko Miura
1Department of Obstetrics and Gynecology, Nagasaki University Graduated School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, and Yasunaga Obstetrics and Gynecology Hospital, Isahaya, Japan. shimachan-ngs@umin.ac.jp
Objective:
Human papilloma virus (HPV) can cause cervical cancer. Risk factors for HPV infection are primarily related to sexual behavior. We determined the prevalence of HPV infection and abnormal cervical cytology in institutionalized women with no previous sexual experience.
Methods:
The study subjects were 251 patients who sought screening for cervical cancer (45.9+/-9.4 years, mean+/-S.D., range, 14 to 66). They were institutionalized for psychosomatic disorders since childhood, and had no previous sexual experience. In addition to screening for cervical cancer, specimens for HPV testing were collected.
Results:
No women who were positive for HPV DNA was detected, though 251 women without sexual experiences were screened by the hybrid capture 2 test including 26 types of HPV-DNA.
Conclusion:
Transmission through means other than sexual intercourse may not exist because we could not detect HPV DNA in 251 women with no previous sexual experience.
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