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Analytical methodologies for the determination of omeprazole: an overview
M Espinosa Bosch1, A J Ruiz Sánchez, F Sánchez Rojas
1Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Seville, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|May 29, 2007
Summary
Omeprazole effectively controls gastric acid secretion, showing higher potency than H2-receptor antagonists. This review covers analytical methods for determining omeprazole in various samples, from its inception to present day.
Area of Science:
- Pharmacology
- Analytical Chemistry
Background:
- Omeprazole is a potent gastric acid pump inhibitor.
- It exhibits superior antisecretory activity compared to histamine H(2)-receptor antagonists.
Purpose of the Study:
- To provide an overview of analytical methodologies for omeprazole determination.
- To cover methods used from the drug's origin to the present.
Main Methods:
- Spectrophotometry
- High-performance liquid chromatography with ultraviolet detection (HPLC-UV)
- Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)
Main Results:
- Various analytical techniques have been employed to quantify omeprazole.
- These methods are applicable to both pharmaceutical formulations and biological fluids.
Conclusions:
- A range of validated analytical methods exist for omeprazole.
- These methods are crucial for quality control and pharmacokinetic studies.
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