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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Coupled positive feedbacks provoke slow induction plus fast switching in apoptosis

Hyung-Seok Choi1, Soohee Han, Hiroki Yokota

  • 1Interdisciplinary Program in Bioinformatics, Seoul National University, Gwanak-Gu, Seoul, Republic of Korea.

FEBS Letters
|May 29, 2007
PubMed
Summary

Programmed cell death, or apoptosis, relies on caspase-3 activation. Mathematical modeling reveals two positive feedbacks involving caspase-8 and XIAP are crucial for this slow induction and rapid execution mechanism.

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