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Updated: Jul 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis
Rachelle Donn1, Debbie Payne, David Ray
1Arthritis Research Campaign Epidemiology Unit (ARC/EU) and Centre for Molecular Medicine (CMM), University of Manchester, Manchester, UK.
Background:
A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA).
Objective:
To investigate polymorphisms of the glucocorticoid receptor (GR) gene and determine any associations with RA.
Methods:
Three GR polymorphisms that tag 95% of all haplotypes across the GR gene were genotyped. These are an intron B Bcl1 polymorphism, a ttg insertion/deletion within intron F (rs2307674) and the single nucleotide polymorphism (SNP) lying in the 3' untranslated region of exon 9b (rs6198). The dye terminator-based SNaPshot method or size resolution by capillary electrophoresis was performed. The study population comprised 198 UK Caucasian RA cases and 393 ethnically matched controls.
Results:
No significant single point or haplotypic associations were found for GR polymorphisms with RA susceptibility. Furthermore, no evidence for GR polymorphisms with aspects of RA severity was seen.
Conclusion:
In this study of the most comprehensive coverage of GR polymorphisms with RA, no significant contributing role for GR polymorphisms with RA was found.
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