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Association between carotid artery intima-media thickness and early-stage CKD in a Chinese population

Luxia Zhang1, Feng Zhao, Ying Yang

  • 1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|May 30, 2007
PubMed

Insights

Increased carotid artery intima-media thickness (IMT) is linked to chronic kidney disease (CKD) in Chinese adults over 40. Cardiovascular disease risk factors appear to explain this association in early-stage CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Increased carotid artery intima-media thickness (IMT) is a predictor of vascular events in the general population.
  • The association between IMT and chronic kidney disease (CKD) has been underexplored in early-stage CKD populations.

Purpose of the Study:

  • To investigate the relationship between carotid artery IMT and early-stage CKD in a Chinese population.
  • To determine if CKD markers like estimated glomerular filtration rate (eGFR) and albuminuria correlate with IMT.

Main Methods:

  • A cross-sectional study involving 1,046 residents over 40 years old in Beijing.
  • Carotid artery IMT measured using high-resolution B-mode ultrasonography.
  • eGFR calculated using the modified Modification of Diet in Renal Disease Study equation; albuminuria assessed via urinary albumin-creatinine ratio.

Main Results:

  • Mean IMT was significantly higher in subjects with lower eGFR (60-89 mL/min/1.73 m² and 30-59 mL/min/1.73 m²) compared to those with eGFR >90 mL/min/1.73 m² (P < 0.001).
  • Subjects with albuminuria exhibited higher IMT compared to those without (P < 0.001).
  • While eGFR and albuminuria correlated with IMT in univariable analysis, this association did not persist after adjusting for cardiovascular disease risk factors.

Conclusions:

  • Carotid artery IMT is significantly elevated in Chinese individuals over 40 with early-stage CKD.
  • The observed increase in IMT among CKD patients may be attributable to a higher prevalence of traditional cardiovascular disease risk factors.
Abstract

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