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Published on: January 9, 2026
Autoimmune pancreatitis
Alyssa M Krasinskas1, Amit Raina, Asif Khalid
1Department of Pathology, University of Pittsburgh, UPMC - Presbyterian, 200 Lothrop Street, A610, Pittsburgh, PA 15213, USA. krasinskasam@upmc.edu
Abstract:
Autoimmune pancreatitis (AIP) is a benign, IgG4-related, fibroinflammatory form of chronic pancreatitis that can mimic pancreatic ductal adenocarcinoma both clinically and radiographically. Laboratory studies typically demonstrate elevated serum IgG4 levels and imaging studies reveal a diffusely or focally enlarged pancreas with associated diffuse or focal narrowing of the pancreatic duct. The pathologic features include periductal lymphoplasmacytic inflammation, obliterative phlebitis, and abundant IgG4-positive plasma cells. The treatment of choice for AIP is steroid therapy. Diagnostic criteria for AIP have been proposed that incorporate histologic, radiographic, serologic, and clinical information.
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