Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Visual Agnosia01:12

Visual Agnosia

Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round end"...
Prosopagnosia01:24

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Dupilumab as a corticosteroid-sparing adjunct in severe mucocutaneous pemphigus vulgaris with prior avascular necrosis and chronic kidney disease.

Frontiers in medicine·2026
Same author

Living environments and mental symptoms and disorders.

BMC psychiatry·2026
Same author

SSGJ-608 in moderate-to-severe plaque psoriasis: a multicenter, randomized, open-label, phase 3 study.

Frontiers in immunology·2026
Same author

Associations between socioeconomic factors and mental symptoms highlight whole-body correlates and pathways.

iScience·2026
Same author

Peripheral inflammation mediates the association between triglyceride-glucose index and cognitive impairment in comorbid major depressive disorder and type 2 diabetes: Translational implications for Alzheimer's disease risk via neuroinflammatory pathways.

Journal of affective disorders·2026
Same author

Genome-wide association studies of brain diffusion kurtosis imaging phenotypes.

EBioMedicine·2026

Related Experiment Video

Updated: Jul 14, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Whole brain functional connectivity in the early blind.

Yong Liu1, Chunshui Yu, Meng Liang

  • 1National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China.

Brain : a Journal of Neurology
|May 30, 2007
PubMed
Summary

Brain changes in early blindness show both general loss and compensatory plasticity. Resting-state fMRI reveals decreased connections, but stronger connections with Braille use, suggesting integrated neural adaptations.

More Related Videos

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
11:57

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Related Experiment Videos

Last Updated: Jul 14, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
11:57

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Sensory processing

Background:

  • Early visual deprivation leads to brain alterations, explained by general loss or compensatory plasticity hypotheses.
  • Previous task-based fMRI studies primarily supported compensatory plasticity.
  • Studying resting-state fMRI offers a novel approach to investigate both hypotheses simultaneously in the blind.

Purpose of the Study:

  • To investigate decreased and increased functional connectivities in the early blind using resting-state functional MRI (fMRI).
  • To explore how these connectivities relate to general loss and compensatory plasticity in the absence of vision.

Main Methods:

  • Utilized whole-brain resting-state fMRI data from 16 early blind subjects and age/gender-matched controls.
  • Compared functional connectivities (correlation coefficients between brain regions) between the two groups.
  • Correlated findings with factors like age of blindness onset and Braille practice duration.

Main Results:

  • Early blind subjects showed decreased functional connectivities within occipital visual cortices and with other sensory/motor/multisensory areas, supporting general loss.
  • Earlier Braille introduction and longer practice correlated with stronger functional connectivities, supporting compensatory plasticity.
  • Increased functional connectivities between occipital and frontal language cortices were observed in early-onset blindness, indicating predominant compensatory plasticity.

Conclusions:

  • Resting-state fMRI reveals that brain changes in early blindness reflect an integrated interplay of general loss and compensatory plasticity.
  • Functional connectivity patterns provide insights into neural reorganization following sensory deprivation.
  • The findings highlight the brain's capacity for adaptation and the specific role of sensory substitution methods like Braille.