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Inverse relationship between serum levels of interleukin-1beta and testosterone in men with stable coronary artery

J E Nettleship1, P J Pugh, K S Channer

  • 1Hormone & Vascular Biology Group, Academic Unit of Diabetes Endocrinology & Metabolism, The University of Sheffield Medical School, Sheffield, UK.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 30, 2007
PubMed

Insights

This study found that higher coronary artery disease severity in men correlated with increased levels of inflammatory cytokines Interleukin-1 beta (IL-1beta) and Interleukin-10 (IL-10). Testosterone may regulate IL-1beta activity in these patients.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Endocrinology

Background:

  • Testosterone has shown benefits in managing myocardial ischemia in men with coronary artery disease (CAD).
  • Inflammatory cytokines play a role in atherosclerosis, but their interaction with testosterone in the cardiovascular system is not well understood.

Purpose of the Study:

  • To investigate the relationship between serum inflammatory cytokine levels and testosterone in men with stable coronary artery disease (CAD).

Main Methods:

  • Serum samples were collected from 69 men with significant coronary artery occlusion.
  • Levels of total testosterone, bioavailable testosterone, tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-10 were measured.
  • Analysis was performed based on the number of diseased coronary vessels and testosterone levels (hypogonadal, borderline hypogonadal, eugonadal).

Main Results:

  • Significant stepwise increases in IL-1beta and IL-10 levels were observed with increasing severity of CAD (1, 2, or 3 vessel disease).
  • A significant stepwise increase in IL-1beta levels was also noted across eugonadal, borderline hypogonadal, and hypogonadal men.
  • No significant differences were observed in TNFalpha or IL-6 levels across CAD severity or testosterone status.

Conclusions:

  • IL-1beta and IL-10 are implicated in the pathogenesis of coronary artery disease.
  • Testosterone may play a regulatory role in IL-1beta activity among men with CAD.
Abstract

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