Related Experiment Video
Updated: Jul 14, 2026
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
Published on: July 5, 2024
[Re-osseointegration of peri-implantitis bone defects: an experimental study in dogs]
De-rong Zou1, Hong Zhu, Xiao-hui Qu
1Department of Stomatology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China. drzou@citiz.net
Purpose:
To investigate the treatment methods of experimentally induced peri-implantitis bone defects, and evaluate bone regeneration and re-osseointegration around implants histologically.
Methods:
30 Brinemark standard implants were placed in 5 Beagle dogs' mandibles to establish peri-implantitis bone defect model, then bone defects were randomly treated with: (1) debridement alone; (2) debridement plus guided bone regeneration using non-absorbable membrane; (3) debridement plus non-absorbable membrane associated with bone graft; (4) debridement plus non-absorbable membrane associated with biological activity glass. Peri-implant bone augmentation was observed and detected by radiography, fluorescence light micrography, un-decalcified bones ground section and direct measurement on operation. SPSS 12.0 software package was used for ANOVA, Kruskal-Wallis test and Mann-Whiteney test.
Results:
There were significant differences between four groups in peri-implant bone augmentation, bone contact level and bone mineralization apposition rate, P < 0.05. The group using debridement plus non-absorbable membrane associated with bone graft resulted in a greater amount of regeneration than the other treatments.
Conclusion:
Inflammation induced peri-implant bone defects can regenerate by appropriate treatment. Supported by Shanghai Municipal Science and Technology Enhancement Award (Grant No.024119072).
