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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
Inherited, familial and sporadic primary open-angle glaucoma.
Gordon Gong1, Sade Kosoko-Lasaki, Gleb Haynatzki
1West Texas EXPORT Center, F. Marie Hall Institute for Rural and Community Health, Texas Tech University Health Science Center, Lubbock, TX 79409 USA. gordon.gong@ttuhsc.edu
Journal of the National Medical Association
|May 31, 2007
Summary
Family history is crucial for understanding primary open-angle glaucoma (POAG). Classifying POAG into inherited, familial, and sporadic types aids genetic research and clinical practice.
Area of Science:
- Ophthalmology
- Genetics
- Medical Research
Background:
- Growing awareness of family history's medical value.
- Need for further investigation into familial aggregation of diseases.
- Primary open-angle glaucoma (POAG) exhibits significant familial clustering.
Purpose of the Study:
- To propose a classification system for POAG based on inheritance patterns.
- To differentiate POAG subtypes for improved genetic studies.
- To highlight the role of genetic predisposition in POAG.
Main Methods:
- Review of published data on POAG inheritance and gene mapping.
- Analysis of linkage and association studies for different POAG categories.
- Development of a mathematical model for prevalence and mutation frequency estimation.
Main Results:
- POAG can be categorized into inherited, familial, and sporadic forms.
- Inherited POAG follows Mendelian patterns, linked to seven loci.
- Familial POAG lacks clear Mendelian patterns but shows aggregation.
- Sporadic POAG cases often harbor known mutations, indicating genetic influence.
- Inherited and familial POAG may constitute up to 72% of all cases.
Conclusions:
- POAG is primarily driven by genetic predisposition interacting with other factors like age.
- The proposed POAG classification can guide clinical practice and genetic research.
- Ethnic background and familial aggregation are critical considerations in POAG studies.
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