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[Serum uric acid and factor VII hyperactivity in the elderly].

K Kario1, T Matsuo

  • 1Department of Internal Medicine, Hyogo Prefectural Awaji Hospital.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|September 1, 1991
PubMed
Summary

Serum uric acid levels correlate with coagulation factor VII (FVII) and lipids in elderly men. Elevated uric acid may indicate coronary risk in older men due to higher FVII levels.

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Clinical Chemistry

Context:

  • The elderly population faces increased risks for cardiovascular diseases.
  • Understanding metabolic and hemostatic factors in aging is crucial for risk assessment.

Purpose:

  • To investigate the association between serum uric acid, lipid profiles, and coagulation factor VII (FVII) in elderly individuals.
  • To determine if serum uric acid is an independent risk factor for cardiovascular disease in the elderly.

Summary:

  • Serum uric acid levels showed significant correlations with coagulation factor VII (FVIIc and FVIIag) and various lipid fractions (triglycerides, VLDL, LDL, total cholesterol) and cholinesterase activity (ChE) in elderly men.
  • These correlations were not significant in women.
  • Multiple regression analysis indicated that the association between uric acid and FVII in men was not independent of triglycerides and VLDL.

Impact:

  • The findings suggest that elevated serum uric acid may be a potential coronary risk factor in elderly men, possibly mediated by higher FVII levels.
  • This research highlights the complex interplay of metabolic and hemostatic factors in cardiovascular risk among the aging population.

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