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[Gastric xanthomas in the elderly].

M Naito1, S Miura, C Funaki

  • 1Department of Geriatrics, Nagoya University School of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|September 1, 1991
PubMed
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Gastric xanthomas, lipid-filled lesions in the stomach lining, are common in the elderly. They often appear with atrophic gastritis and may indicate pathological aging of the gastric mucosa.

Area of Science:

  • Gastroenterology
  • Pathology
  • Geriatrics

Context:

  • Gastric xanthomas are benign, lipid-laden lesions in the stomach, often overlooked due to limited literature.
  • Their clinical significance and association with gastric pathology remain largely unknown.
  • This study investigates gastric xanthomas in an elderly population undergoing gastroendoscopy.

Purpose:

  • To determine the prevalence and characteristics of gastric xanthomas in the elderly.
  • To explore the association between gastric xanthomas and gastric mucosal changes.
  • To assess the potential role of gastric xanthomas as a marker of gastric aging.

Summary:

  • 131 elderly individuals (average age 75.6) were analyzed for gastric xanthomas.
  • Gastric xanthomas were observed in 40.5% of males and 25.8% of females, increasing with age, particularly in the seventies.

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  • Most xanthomas were solitary, located in the antrum and pylorus, and associated with atrophic gastritis (89%), gastric pit hyperplasia, and intestinal metaplasia, but not serum lipid levels or H. pylori infection.

    • Impact:

    • Gastric xanthomas in the elderly are frequently linked to atrophic mucosal changes, suggesting localized lipid metabolism disturbances.
    • The findings indicate that gastric xanthomas may serve as a potential biomarker for pathological aging of the gastric mucosa.
    • Further research is warranted to elucidate the precise mechanisms and clinical implications of gastric xanthomas.