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Population-based reference values for bone mineral density in young men.

M Høiberg1, T L Nielsen, K Wraae

  • 1Department of Endocrinology, Odense University Hospital, DK-5000 Odense C, Denmark. mikkelhoiberg@gmail.com

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|May 31, 2007
PubMed
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Establishing population-based reference values for bone mineral density (BMD) in Danish men is crucial. Locally derived BMD values are important for accurate osteoporosis diagnosis in men.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Public Health

Background:

  • Bone mineral density (BMD) and peak bone mass are influenced by geographic, ethnic, and socioeconomic factors.
  • Limited reference values exist for male peak bone mass, leading to reliance on manufacturer data for osteoporosis diagnosis.
  • Dual-energy X-ray absorptiometry (DXA) equipment manufacturers' data may not accurately reflect diverse populations.

Purpose of the Study:

  • To establish population-based reference values for BMD in young Danish men.
  • To investigate the impact of specific variables on bone metabolism and BMD in this cohort.
  • To provide accurate reference data for the diagnosis of male osteoporosis.

Main Methods:

  • The study included 783 Caucasian men aged 20-30 years from the Odense Androgen Study (OAS).

Related Experiment Videos

  • Population-based reference values for BMD were determined for the total hip and lumbar spine.
  • Subgroup analyses were conducted based on factors potentially affecting bone metabolism.

    • Main Results:

    • Peak bone mineral density (BMD) was achieved by the third decade of life.
    • Obesity (BMI > 30 kg/m2) correlated with higher BMD, while anabolic steroid abuse and chronic illness were associated with lower BMD.
    • Significant differences were observed between the study's hip BMD values and NHANES III data, and between lumbar spine BMD and Hologic values.

    Conclusions:

    • Locally derived reference values for BMD are essential for accurate osteoporosis assessment in men.
    • Using population-specific data prevents misdiagnosis (false positives or negatives).
    • This study provides crucial reference data for Danish men, improving diagnostic accuracy.