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Related Experiment Video

Updated: Jul 14, 2026

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements

Published on: May 1, 2017

Standard reference materials for foods and dietary supplements.

Katherine E Sharpless¹, Jeanice Brown Thomas, Steven J Christopher

¹Analytical Chemistry Division, National Institute of Standards and Technology, 100 Bureau Drive Stop 8390, Gaithersburg, MD 20899-8390, USA. katherine.sharpless@nist.gov

Analytical and Bioanalytical Chemistry

|May 31, 2007

Summary

The National Institute of Standards and Technology (NIST) develops certified reference materials for food and dietary supplements. These standard reference materials (SRMs) ensure accurate nutrient labeling and support analytical method validation for consumer safety.

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Area of Science:

Analytical Chemistry
Food Science
Pharmacognosy

Background:

Laboratories require well-characterized certified reference materials for accurate food and dietary supplement analysis.
Legislation like the Nutrition Labeling and Education Act and the Dietary Supplement Health and Education Act drives the need for reliable standards.
The National Institute of Standards and Technology (NIST) has developed numerous food-matrix and dietary supplement Standard Reference Materials (SRMs).

Discussion:

NIST's food-matrix SRMs cover a range of products including diet composites, meat, oyster tissue, infant formula, fish tissue, baby food, chocolate, spinach, and peanut butter.
Dietary supplement SRMs are characterized for active compounds, marker compounds, toxic elements, and pesticides, with examples including cod liver oil, ephedra, carrot extract, and ginkgo.
Some dietary supplements, when food-like, also have nutrient values assigned, such as Ephedra-Containing Protein Powder.

Key Insights:

These SRMs are crucial for validating analytical methods used in food and dietary supplement testing.
They serve as primary control materials for assigning values to secondary control materials.
Accurate measurement traceability to NIST is established through the use of these reference materials.

Outlook:

NIST continues to develop new food-matrix and dietary supplement SRMs to meet evolving laboratory needs.
Expansion of SRMs for novel food products and complex dietary supplement formulations is anticipated.
Enhanced availability of reference materials will further support regulatory compliance and consumer protection.