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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Biometric indices evaluation in central retinal vein occlusion using partial coherence laser interferometry
S Moghimi1, A Mirshahi, A Lasheie
1Farabi Eye Research Center, Department of Ophthalmology, Tehran Univ of Medical Sciences, Tehran, Iran. sasanimii@yahoo.com
European Journal of Ophthalmology
|May 31, 2007
Summary
Eyes with central retinal vein occlusion (CRVO) may have a shorter posterior segment length, potentially increasing crowding and risk of CRVO. This finding aids in understanding CRVO development.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
- Ocular Biometry
Background:
- Central retinal vein occlusion (CRVO) is a significant cause of vision loss.
- Understanding predisposing anatomical factors for CRVO is crucial for prevention and management.
Purpose of the Study:
- To investigate the relationship between ocular axial length, posterior segment length, and central retinal vein occlusion.
- To compare biometric parameters of affected and fellow eyes in patients with unilateral CRVO.
Main Methods:
- Optical coherence interferometry was used to measure mean keratometry, axial length (AL), anterior chamber depth (ACD), and posterior segment length (PSL).
- A cohort of 29 patients with unilateral CRVO (excluding macular edema) was studied.
- PSL was calculated as AL minus ACD.
Main Results:
- No significant differences were found in mean keratometry or ACD between affected and unaffected eyes.
- Affected eyes showed a trend towards shorter axial length, but this was not statistically significant.
- A statistically significant shorter posterior segment length was observed in eyes with CRVO compared to their fellow eyes (p=0.008).
Conclusions:
- Eyes with central retinal vein occlusion may exhibit a shorter posterior segment length.
- This anatomical characteristic could contribute to increased crowding of the central retinal vein and artery within the lamina cribrosa, potentially predisposing individuals to CRVO.
