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Serum prolactin levels and Behçet disease.

H Proença¹, C Ferreira, M Miranda

¹Department of Ophthalmology, Visual Sciences Research Centre, University of Lisbon, Lisbon, Portugal. helenprocenca@hotmail.com

European Journal of Ophthalmology

|May 31, 2007

Summary

Serum prolactin levels are elevated in Behçet disease (BD) patients, particularly those with complete-type BD, suggesting a role for prolactin in disease pathogenesis and expression.

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Area of Science:

Endocrinology
Immunology
Rheumatology

Background:

Behçet disease (BD) is a chronic inflammatory disorder of unknown etiology.
Hormonal imbalances may play a role in the pathogenesis of BD.

Purpose of the Study:

To investigate serum prolactin levels in patients with Behçet disease.
To correlate prolactin levels with the clinical phenotype of Behçet disease.

Main Methods:

A prospective, nonrandomized comparative study included 22 BD patients and 21 healthy controls.
Serum prolactin levels were measured using electrochemiluminescence immunoassay.
BD patients were subcategorized into complete-type and incomplete-type based on clinical manifestations.

Main Results:

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Serum prolactin levels were significantly higher in BD patients compared to controls (p=0.009).
Elevated prolactin levels were also observed in the complete-type BD subgroup compared to controls (p=0.02).
Younger patients (<30 years) showed a trend towards requiring more aggressive treatment, suggesting a link between age and disease severity.

Conclusions:

Serum prolactin may be implicated in the pathogenesis of Behçet disease.
Prolactin levels are associated with the clinical expression of BD, especially in complete-type disease.