Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sibling stem cell donor experiences at a single institution.

Lori S Wiener1, Emilie Steffen-Smith, Haven B Battles

  • 1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. wienerl@mail.nih.gov

Psycho-Oncology
|May 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell genomics links targeted functional manipulations to efficacy-associated chromatin signatures in CAR T cells.

Research square·2026
Same author

Feasibility and Safety of a Novel CD19-Directed CAR T-Cell Therapy in Patients with R/R B-Cell Non-Hodgkin Lymphoma.

Transplantation and cellular therapy·2026
Same author

Outcomes following CD22 CAR T-cells in B-ALL: a tale of two manufacturing strategies.

Cytotherapy·2025
Same author

Talicabtagene autoleucel for relapsed or refractory B-cell malignancies: results from an open-label, multicentre, phase 1/2 study.

The Lancet. Haematology·2025
Same author

Anti-CD7 allogeneic WU-CART-007 in patients with relapsed/refractory T-cell acute lymphoblastic leukemia/lymphoma: a phase 1/2 trial.

Research square·2024
Same author

FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.

Nature immunology·2023

Peripheral blood stem cell (PBSC) sibling donors need more information and support. This study highlights their fears and unmet needs during the donation process, suggesting improvements for future care.

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Donor Psychology

Background:

  • Allogeneic stem cell transplantation, using bone marrow (BM) or peripheral blood stem cells (PBSC), offers curative potential for hematologic diseases.
  • Sibling donors are frequently chosen, but research has predominantly focused on BM donors, leaving PBSC sibling donor experiences underexplored.

Purpose of the Study:

  • To explore the experiences, needs, and concerns of sibling donors undergoing peripheral blood stem cell donation.
  • To identify areas for improvement in supporting PBSC sibling donors.

Main Methods:

  • Retrospective interviews were conducted with 14 sibling donors at a single institution.
  • A qualitative, structured design allowed donors to freely express their perspectives.

Related Experiment Videos

Main Results:

  • Sibling donors reported fears regarding the stem cell collection procedure.
  • Donors expressed a significant need for enhanced information about transplant outcomes and potential complications.
  • The study design facilitated open communication, unhindered by external influences.

Conclusions:

  • Peripheral blood stem cell sibling donors have specific psychological and informational needs that require attention.
  • Educational tools and psychosocial interventions should be developed to better support these donors.
  • Further research is recommended to optimize the sibling donor experience in transplantation.