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Linkage analysis of affective disorder using DNA markers on chromosomes 11 and X
S Nanko1, M Kobayashi, S Gamou
1Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
The Japanese Journal of Psychiatry and Neurology
|March 1, 1991
Abstract:
We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c-Ha-ras-1 oncogene and the insulin gene on chromosome 11, or hypoxanthine phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.