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Updated: Jul 14, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Lifetime cost-utility analysis of patients with refractory epilepsy treated with adjunctive topiramate therapy :
Objective:
To evaluate the cost-effectiveness profile of topiramate as adjunctive treatment in patients with refractory epilepsy.
Study Design:
Lifetime cost-utility analysis based on a pharmacoeconomic model.
Methods:
Effectiveness data (seizure frequency reduction) were derived from the most recent placebo-controlled clinical trial, whilst quality of life and cost data were retrieved from the published literature. Our pharmacoeconomic model was based on a patient-level approach that incorporated the clinical data of the randomised, controlled trial.
Main Outcome Measures And Results:
Our analysis showed that chronic topiramate treatment costs pound21 353 per quality-adjusted life year (QALY) gained (incremental lifetime cost of pound1 024 941 and incremental utility of 48 QALYs, for every 100 patients) [discounted values with a yearly rate of 3%] (year of costing 2001). Sensitivity analyses suggested a range from pound19 915 to pound24 518 per QALY gained.
Conclusions:
Our results showed that adjunctive topiramate therapy has a favourable pharmacoeconomic profile in patients with refractory epilepsy.
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