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Updated: Jul 14, 2026

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
Published on: August 20, 2021
The role of fibroblasts in tissue engineering and regeneration
T Wong1, J A McGrath, H Navsaria
1Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, The Guy's, King's and St Thomas' School of Medicine, London, UK.
Abstract:
Fibroblasts are mesenchymal cells that can be readily cultured in the laboratory and play a significant role in epithelial-mesenchymal interactions, secreting various growth factors and cytokines that have a direct effect on epidermal proliferation, differentiation and formation of extracellular matrix. They have been incorporated into various tissue-engineered products such as Dermagraft (Advanced BioHealing, La Jolla, CA, U.S.A.) and Apligraf (Novartis, Basel, Switzerland) and used for a variety of clinical applications, including the treatment of burns, chronic venous ulcers and several other clinical applications in dermatology and plastic surgery. In this article we review the cell biology of dermal fibroblasts and discuss past and current experience of the clinical use of cultured fibroblasts.
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