Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Periodontitis is characterized by elevated PAI-1 activity.

S Bizzarro1, U van der Velden, J M A G ten Heggeler

  • 1Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, Amsterdam, The Netherlands. s.bizzarro@acta.nl

Journal of Clinical Periodontology
|May 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A double-blind randomised controlled trial assessing the effect of menaquinone producing probiotics on vitamin K status.

Beneficial microbes·2026
Same author

A selective machine learning algorithm for severe periodontitis labeling from questionnaire data.

Scientific reports·2026
Same author

Longitudinal proteomic analysis of GCF in regenerative healing of molar furcation degree II defects treated with OFD, EMD, or A-PRF + : a pilot study.

Scientific reports·2026
Same author

Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire.

BMC geriatrics·2026
Same author

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies.

Kidney medicine·2026
Same author

Evaluation of donor's hormonal profile according to sex and age.

Frontiers in physiology·2025
Same journal

Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling.

Journal of clinical periodontology·2026
Same journal

Correction to ''Clinical Efficacy of Interventions Based on Professional Mechanical Plaque Removal in the Treatment of Dental Biofilm-Induced Gingivitis: A Systematic Review and Meta-Analysis''.

Journal of clinical periodontology·2026
Same journal

Extracellular Vesicles From Young Brain-Mediated Delivery of PRDX3 Ameliorates Alveolar Bone Loss in Periodontitis.

Journal of clinical periodontology·2026
Same journal

Cost Consequence Analysis of Non-Surgical Treatment Approaches for Patients With Periodontitis.

Journal of clinical periodontology·2026
Same journal

Management of Non-Plaque-Induced Gingival Conditions: A Systematic Review-Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation.

Journal of clinical periodontology·2026
Same journal

Ten-Year Results of a Prospective Case Series on Immediately Provisionalized One-Piece Alumina-Toughened Zirconia (ATZ) Oral Implants for Single-Tooth Restoration and Three-Unit Fixed Dental Prostheses.

Journal of clinical periodontology·2026
See all related articles

Periodontitis patients show elevated plasminogen activator inhibitor-1 (PAI-1) activity, indicating a prothrombotic state. This finding suggests a potential link between untreated periodontitis and increased cardiovascular disease (CVD) risk.

Area of Science:

  • Periodontology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Periodontitis, a chronic infectious disease, is increasingly associated with cardiovascular diseases (CVD).
  • A prothrombotic state, characterized by an imbalance in blood coagulation and fibrinolysis, may mediate this association.
  • Understanding the prothrombotic markers in periodontitis is crucial for assessing CVD risk.

Purpose of the Study:

  • To investigate elevated plasma levels of prothrombotic state markers in periodontitis patients compared to healthy controls.
  • To assess specific markers including von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), plasminogen activator inhibitor-1 (PAI-1) activity, and D-dimer.

Main Methods:

  • Recruitment of untreated patients with moderate (n=53) and severe periodontitis (n=38), alongside healthy controls (n=39).

Related Experiment Videos

  • Measurement of plasma levels for vWF, F1+2, PAI-1 activity, and D-dimer.
  • Statistical analysis to compare marker levels among the three groups, adjusting for potential confounders.

    • Main Results:

    • Patients with periodontitis exhibited significantly higher erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and leucocyte counts (WBC).
    • No significant differences were observed in vWF, F1+2, or D-dimer levels among the groups.
    • PAI-1 activity was significantly elevated in the severe periodontitis group, even after adjustment (p(adj)=0.004).
    • A higher proportion of periodontitis patients had vWF and PAI-1 levels above population medians.

    Conclusions:

    • Periodontitis is associated with elevated plasminogen activator inhibitor-1 (PAI-1) activity compared to healthy individuals.
    • Elevated PAI-1 may lead to impaired fibrinolysis, contributing to a prothrombotic state.
    • This prothrombotic state in untreated periodontitis could increase the risk for cardiovascular diseases (CVD).