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[Clinical analysis of infectious complications following abdominal cluster transplantation]

Hui-xing Chen1, Lu Yin, Cheng-hong Peng

  • 1Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|May 31, 2007
PubMed
Abstract

Insights

Postoperative infections are complex after abdominal cluster transplantation. Optimizing immunosuppression and early diagnosis are key to reducing complications in these patients.

Area of Science:

  • Surgical transplantation
  • Infectious disease management
  • Immunosuppression protocols

Background:

  • Abdominal cluster transplantation is a complex procedure.
  • Postoperative infections pose significant challenges.

Observation:

  • Two cases of abdominal cluster transplantation, including small intestine, were reviewed.
  • Patients received a combination of five immunosuppressive agents, including tacrolimus.
  • Severe Gram-negative bacillus and invasive fungal infections (Candida species) were observed.

Findings:

  • Cytomegalovirus (CMV) infection was identified, leading to changes in monocyte counts and T-cell ratios.
  • CMV matrix proteins (CMV-pp71) were detected in bile via PCR.
  • Liver transplant biopsies showed microabscesses.

Implications:

  • Infectious complications following cluster transplantation are intricate.
  • Strategies for optimizing immunosuppression are crucial.
  • Early diagnosis and prompt treatment are vital for reducing infection rates.

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