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[Abnormal myocardial perfusion after infarction in patients with persistent TIMI grade-3 flow. Only an acute

Vicente Bodí1, Juan Sanchis, Julio Núñez

  • 1Servicio de Cardiología, Hospital Clínico y Universitario de Valencia, Universidad de Valencia, Valencia, Spain. vicentbodi@hotmail.com

Revista Espanola De Cardiologia
|May 31, 2007
PubMed
Abstract

Insights

Myocardial contrast echocardiography (MCE) reveals that perfusion defects after myocardial infarction (MI) can persist long-term. These chronic perfusion abnormalities correlate with impaired left ventricular function and increased volumes.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Myocardial Perfusion Imaging

Background:

  • Myocardial infarction (MI) can lead to microcirculation dysfunction.
  • Previous studies suggested transient perfusion abnormalities post-MI with TIMI 3 flow.
  • The persistence of myocardial perfusion defects requires further investigation.

Purpose of the Study:

  • To investigate the persistence of myocardial perfusion defects in the chronic phase after MI.
  • To determine the relationship between chronic perfusion defects and left ventricular remodeling and function.

Main Methods:

  • Forty-seven patients with MI and TIMI 3 flow were assessed.
  • Intracoronary myocardial contrast echocardiography (MCE) was performed 1 week and 6 months post-MI.
  • Abnormal perfusion was defined as >1 hypoperfused segment on MCE.

Main Results:

  • Twenty patients had abnormal perfusion at 1 week post-MI.
  • Ten patients showed persistent abnormal perfusion at 6 months.
  • Patients with chronic perfusion defects exhibited larger left ventricular volumes and reduced ejection fraction.

Conclusions:

  • Myocardial contrast echocardiography can detect persistent perfusion defects in the chronic phase after MI.
  • Chronic perfusion abnormalities are associated with more severe systolic dysfunction.
  • Persistent defects correlate with increased left ventricular volumes post-MI.

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