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[Urinary NT-proBNP level: relationship with ventricular function parameters in heart failure]
Esther Roselló-Lletí1, Miguel Rivera, Vicente Miró
1Unidad de Cardiología, Centro de Investigación Hospital La Fe, Valencia, Spain.
Revista Espanola De Cardiologia
|May 31, 2007
Summary
Urinary N-terminal probrain natriuretic peptide (NT-proBNP) levels correlate with left ventricular function in heart failure patients. This finding supports using urinary NT-proBNP as a non-invasive biomarker for assessing ventricular function.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Plasma N-terminal probrain natriuretic peptide (NT-proBNP) is a sensitive indicator of ventricular dysfunction.
- Urinary NT-proBNP measurement has demonstrated diagnostic and prognostic value.
Purpose of the Study:
- To investigate the relationship between established left ventricular function parameters and urinary NT-proBNP levels.
- To evaluate urinary NT-proBNP as a potential biomarker in heart failure.
Main Methods:
- The study included 74 heart failure patients.
- Doppler echocardiography assessed atrioventricular plane displacement (AVPD), ejection fraction, and mitral flow propagation velocity.
- Urinary and plasma NT-proBNP levels were measured.
Main Results:
- Urinary NT-proBNP levels correlated significantly with AVPD (r=-0.5; P<.0001) and ejection fraction (r=-0.3; P<.01).
- Decreasing urinary NT-proBNP levels were observed with improved AVPD and ejection fraction across quartiles.
- Plasma NT-proBNP was an independent predictor of urinary NT-proBNP, with AVPD and ejection fraction serving as alternative predictors when plasma NT-proBNP was excluded.
Conclusions:
- A significant correlation exists between urinary NT-proBNP levels and left ventricular function parameters.
- Urinary NT-proBNP shows promise as a biochemical marker for assessing ventricular function in heart failure patients.
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