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Quantitative liver functions in Turner syndrome with and without hormone replacement therapy
Claus Højbjerg Gravholt1, Henrik Enghusen Poulsen, Peter Ott
1Medical Department M (Endocrinology and Diabetes), Aarhus Sygehus, Nørrebrogade, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. ch.gravholt@dadlnet.dk
European Journal of Endocrinology
|May 31, 2007
Summary
Hormone replacement therapy (HRT) effectively reduces elevated liver enzymes in Turner syndrome (TS). However, quantitative liver functions in TS remain comparable to controls and are unaffected by HRT.
Area of Science:
- Endocrinology
- Hepatology
- Genetics
Background:
- Turner syndrome (TS) is associated with elevated liver enzymes in many females.
- Histological examination reveals diverse hepatic changes in TS.
- Hormone replacement therapy (HRT) has been shown to reduce liver enzyme levels in TS.
Purpose of the Study:
- To conduct a detailed investigation of quantitative liver functions in individuals with TS.
- To assess the impact of HRT on liver function in TS.
- To compare liver function in TS with and without HRT against age-matched controls.
Main Methods:
- A randomized crossover study design was employed.
- Participants included women with TS (n=8) and age-matched controls (n=8).
- Quantitative liver function tests included galactose elimination capacity, indocyanine green clearance, antipyrine clearance, and functional hepatic nitrogen clearance (FHNC).
Main Results:
- Elevated liver enzymes in untreated TS were normalized with HRT.
- Hepatic capacities for galactose, indocyanine green, and antipyrine metabolism were normal in TS and unaffected by HRT.
- Functional hepatic nitrogen clearance (FHNC) was marginally reduced in untreated TS compared to controls and showed no significant change with HRT.
Conclusions:
- HRT effectively suppresses elevated liver enzymes in Turner syndrome.
- Quantitative liver functions in individuals with TS are comparable to those of controls.
- HRT does not significantly alter quantitative liver functions in Turner syndrome.
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