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Updated: Jul 14, 2026

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Published on: April 11, 2016
Pathophysiology of pulmonary arterial hypertension
Suma Jain1, Hector Ventura, Ben deBoisblanc
1Section of Pulmonary/Critical Care Medicine, Ochsner Foundation Clinic, Jefferson, USA.
Abstract:
The mechanisms leading to elevations in precapillary pulmonary vascular resistance are complex and likely involve multiple pathways, but the histopathologic sequelae of these processes are restricted to a few findings, primarily neoangiogenesis, intimal and smooth muscle proliferation, vasoconstriction, and/or in situ thrombosis. Regardless of the etiology of pulmonary hypertension, abnormalities in endothelial function are often observed and likely play a central role in mediating structural changes.
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