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Related Experiment Videos

Pistachio nut consumption and serum lipid levels.

Michael J Sheridan1, James N Cooper, Madeline Erario

  • 1Department of Medicine, Inova Fairfax Hospital, Falls Church, VA 22042-3300, USA. michael.sheridan@inova.com

Journal of the American College of Nutrition
|May 31, 2007
PubMed
Summary
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Incorporating pistachios into the diet improved lipid profiles in individuals with moderate hypercholesterolemia. This dietary change, consisting of 15% of daily calories from pistachios, may reduce coronary disease risk.

Area of Science:

  • Cardiovascular Nutrition
  • Nutritional Biochemistry

Background:

  • Clinical and epidemiological studies suggest tree nuts and peanuts benefit serum lipid levels.
  • Moderate hypercholesterolemia is characterized by serum cholesterol greater than 210 mg/dL.

Purpose of the Study:

  • To investigate the effects of pistachio nut consumption on lipid profiles.
  • To assess changes in lipid profiles in free-living subjects with primary, moderate hypercholesterolemia.

Main Methods:

  • A randomized crossover trial involving 15 subjects with moderate hypercholesterolemia.
  • Dietary intervention for four weeks, with 15% of daily caloric intake from pistachio nuts.
  • Measurement of serum lipid levels, lipoproteins, BMI, blood pressure, and nutrient intake.

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Main Results:

  • Pistachio diet significantly decreased saturated fat intake and increased polyunsaturated fat and fiber intake.
  • Significant reductions observed in total cholesterol/HDL-C and LDL-C/HDL-C ratios, and B-100/A-1 ratio.
  • A statistically significant increase in HDL-C was noted; no significant changes in total cholesterol, triglycerides, LDL-C, or VLDL-C.

Conclusions:

  • A diet with 15% of calories from pistachios (approx. 2-3 ounces daily) for four weeks favorably impacts lipid profiles in hypercholesterolemia.
  • Pistachio consumption may contribute to a reduced risk of coronary heart disease.