Related Experiment Video
Updated: Jul 14, 2026
09:52
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Two children with invasive gastrointestinal aspergillosis
Petek Kayiran1, Nafiye Urganci, Feyzullah Cetinkaya
1Department of Pediatrics and Department of Pathology, Sisli Etfal Education and Research Hospital, Istanbul, Turkey.
Indian Pediatrics
|May 31, 2007
Summary
Two infants with invasive gastrointestinal aspergillosis, a serious fungal infection, were successfully treated. This condition presented with weight loss and diarrhea in immunocompromised infants.
Area of Science:
- Pediatric Infectious Diseases
- Mycology
- Immunology
Background:
- Invasive gastrointestinal aspergillosis is a rare but severe fungal infection.
- Immunocompromised infants are particularly susceptible due to immature or compromised immune systems.
Observation:
- Two infants, aged six and four months, presented with significant weight loss and diarrhea.
- Both infants had underlying conditions: combined immunodeficiency and transient hypogammaglobulinemia of infancy.
Findings:
- Gastrointestinal aspergillosis was diagnosed via endoscopy and histopathology.
- Both patients showed a positive clinical response to Amphotericin B treatment.
Implications:
- Early diagnosis and prompt treatment are crucial for managing invasive fungal infections in infants.
- Amphotericin B is an effective therapeutic option for pediatric gastrointestinal aspergillosis.
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