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Updated: Jul 14, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Two children with invasive gastrointestinal aspergillosis

Petek Kayiran1, Nafiye Urganci, Feyzullah Cetinkaya

  • 1Department of Pediatrics and Department of Pathology, Sisli Etfal Education and Research Hospital, Istanbul, Turkey.

Indian Pediatrics
|May 31, 2007
PubMed

Insights

Two infants with invasive gastrointestinal aspergillosis, a serious fungal infection, were successfully treated. This condition presented with weight loss and diarrhea in immunocompromised infants.

Area of Science:

  • Pediatric Infectious Diseases
  • Mycology
  • Immunology

Background:

  • Invasive gastrointestinal aspergillosis is a rare but severe fungal infection.
  • Immunocompromised infants are particularly susceptible due to immature or compromised immune systems.

Observation:

  • Two infants, aged six and four months, presented with significant weight loss and diarrhea.
  • Both infants had underlying conditions: combined immunodeficiency and transient hypogammaglobulinemia of infancy.

Findings:

  • Gastrointestinal aspergillosis was diagnosed via endoscopy and histopathology.
  • Both patients showed a positive clinical response to Amphotericin B treatment.

Implications:

  • Early diagnosis and prompt treatment are crucial for managing invasive fungal infections in infants.
  • Amphotericin B is an effective therapeutic option for pediatric gastrointestinal aspergillosis.

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