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Indapamide decreases plasma adiponectin concentration in patients with essential hypertension
Grzegorz Piecha1, Marcin Adamczak, Jerzy Chudek
1Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
Kidney & Blood Pressure Research
|May 31, 2007
Summary
Indapamide significantly lowered plasma adiponectin levels in hypertension patients, unlike other tested drugs. This reduction may contribute to metabolic disturbances associated with thiazide diuretics.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolic Syndrome
Background:
- Adiponectin, an adipose-specific protein, possesses antiatherogenic and insulin-sensitizing properties.
- Lower plasma adiponectin concentrations are observed in essential hypertension patients compared to healthy individuals.
- The impact of antihypertensive medications on metabolic syndrome components varies.
Purpose of the Study:
- To investigate the effect of 6-month monotherapy with different antihypertensive drugs on plasma adiponectin concentration in patients with essential hypertension.
Main Methods:
- Forty patients with essential hypertension were randomized to receive enalapril, metoprolol, amlodipine, or indapamide.
- Plasma adiponectin, insulin, and glucose levels, along with body fat content, were measured before and after 6 months of treatment.
Main Results:
- Plasma adiponectin concentrations remained unchanged with enalapril, metoprolol, and amlodipine.
- A significant decrease in plasma adiponectin was observed with indapamide treatment (p=0.047).
- Indapamide treatment also led to a significant increase in the HOMA-IR index (p=0.021).
Conclusions:
- Indapamide monotherapy significantly reduced plasma adiponectin levels in patients with essential hypertension.
- This decrease in adiponectin may play a role in the development of carbohydrate metabolism disturbances observed with thiazide-type diuretics.
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