Related Experiment Video
Updated: Jul 14, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[Effect of tacrolimus on the growth cycle of murine hair follicles]
Ting Tian1, Wei-Xin Fan, Ye-Qin Dai
1Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Objective:
To explore the effect of tacrolimus on murine hair follicle cycle.
Method:
Hematoxylin-eosin dyeing and reverse transcription-polymerase chain raction techniques were used.
Results:
Five days after depilation, the hair follicles in both the tacrolimus group and the minoxidil group was in anagen V, while that in the vaseline group was in anagen III. vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were detected in back skin in both the tacrolimus group and the minoxidil group, but not in the vaseline group.
Conclusion:
Tacrolimus can promote the growth of hair by stimulating the hair follicle to enter anagen V in mice, which may be explained by the effects of VEGF and HGF.
Related Concept Videos
Accessory Structures of the Skin: Hair Growth and Types
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
