Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HER-2/neu expression in glioblastoma multiforme.

Denise M Haynik1, Andres A Roma, Richard A Prayson

  • 1Cleveland Clinic Foundation, Cleveland, OH, USA.

Applied Immunohistochemistry & Molecular Morphology : AIMM
|June 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse.

bioRxiv : the preprint server for biology·2025
Same author

Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss.

Cancer research communications·2025
Same author

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease.

Immunity·2025
Same author

Characterization of gastric/gastrointestinal-like immunophenotypes in endometrial endometrioid adenocarcinomas, including endometrioid adenocarcinomas with mucinous differentiation.

Human pathology·2024
Same author

Rapid postradiation malignant transformation of a pilocytic astrocytoma in an adult with neurofibromatosis type 1: illustrative case.

Journal of neurosurgery. Case lessons·2024
Same author

Long non-coding RNA lung cancer-associated transcript-1 promotes glioblastoma progression by enhancing Hypoxia-inducible factor 1 alpha activity.

Neuro-oncology·2024

This study found no evidence of HER-2/neu oncogene expression or amplification in glioblastoma multiforme (GBM). Therefore, HER-2/neu does not appear to be involved in the development of GBM.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The HER-2/neu oncogene encodes a receptor tyrosine kinase involved in cell growth.
  • HER-2/neu overexpression is common in breast cancer but its role in glioblastoma multiforme (GBM) is unclear.
  • Targeted therapies like trastuzumab (Herceptin) are effective against HER-2/neu-positive tumors.

Purpose of the Study:

  • To investigate the expression and gene amplification of HER-2/neu in glioblastoma multiforme (GBM).
  • To determine if HER-2/neu plays a role in the pathogenesis of GBM.

Main Methods:

  • Retrospective analysis of 49 GBM patient samples.
  • Immunohistochemistry (IHC) for HER-2/neu protein detection.
  • Fluorescence in situ hybridization (FISH) for HER-2/neu gene amplification analysis.

Related Experiment Videos

Main Results:

  • All analyzed GBM tumors were negative for HER-2/neu protein expression by IHC.
  • No GBM tumors showed HER-2/neu gene amplification by FISH.
  • Patient demographics and treatment details were recorded.

Conclusions:

  • HER-2/neu protein expression and gene amplification are not detected in GBM.
  • The HER-2/neu oncogene is unlikely to be a significant factor in GBM development or progression.