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Ylva Nilsagard¹, Cecilia Lundholm, Lars-Gunnar Gunnarsson

¹Department of Physiotherapy, Orebro University Hospital, Institution of Clinical Medicine, University of Orebro. ylva.nilsagard@orebroll.se

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Comparative analysis of lung function in supine and sitting positions in patients with moderate multiple sclerosis.

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Timed walks and the Timed Up and Go test show high reproducibility for assessing multiple sclerosis (MS) mobility. A single test session is sufficient for evaluating individuals with moderate MS.

Area of Science:

Neurology
Rehabilitation Medicine
Biomedical Engineering

Background:

Accurate assessment of mobility in multiple sclerosis (MS) is crucial for intervention evaluation.
Understanding the psychometric properties of common mobility tests is essential for reliable clinical practice.
Timed walks and the Timed Up and Go test are frequently used to assess functional mobility in MS populations.

Purpose of the Study:

To determine the reproducibility of the 10-meter and 30-meter timed walks (10TW, 30TW) and the Timed Up and Go (TUG) test.
To establish the smallest detectable change for these mobility assessments in individuals with moderate MS.
To investigate the correlation between these tests in the target population.

Main Methods:

A repeated-measures design with randomization was employed.

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Participants with moderate MS underwent multiple test sessions within a week.

The 10TW was performed three times (self-selected speed), 30TW three times (forced speed), and TUG twice (forced speed).

Main Results:

High reproducibility was observed for all tests (intraclass correlation coefficients ranging from 0.97 to 0.98).
The smallest detectable change varied, with specific values for 10TW and TUG (-23% to +31%).
The 30TW showed differences based on disability level, and strong correlations were found between tests (0.85).

Conclusions:

A single testing session is adequate for evaluating mobility in moderate MS using 10TW, 30TW, or TUG.
The degree of disability must be considered when interpreting the 30TW results for detecting genuine change.
These findings support the use of these tests for reliable mobility assessment in MS.