Related Experiment Video
Updated: Jul 14, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Hypothermia affects translocation of numerous cytoplasmic proteins following global cerebral ischemia
Maria Teilum1, Morten Krogh, Tadeusz Wieloch
1Lab for Experimental Brain Research, BMC A13, Lund University, Sweden. maria.teilum@med.lu.se
Abstract:
Using a decapitation ischemia model, we studied translocation of proteins to and from the cytosol in normothermic (NT) and hypothermic (HT) rat brains. 2D gel analysis identified 74 proteins whose cytosolic level changed significantly after 15 min of ischemia. HT preserved the cytosolic levels of several glycolytic enzymes, as well as many plasticity related proteins, otherwise decreased following NT ischemia. The levels of redox-related proteins was lower in HT than in NT. Our results indicate that translocation of proteins to and from the cytosol is an important issue during ischemia.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Decreased Body Temperature
Cytotoxic Edema: Pathophysiology
Cellular Injury IV: Necrosis
Responses to Heat and Cold Stress

