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Is there an association between blood group O and epistaxis?
V M Reddy1, M Daniel, E Bright
1Department of Otorhinolaryngology, Leicester Royal Infirmary, Leicester, UK. vmreddy@doctors.net.uk
The Journal of Laryngology and Otology
|June 1, 2007
Summary
Blood group O may increase the risk of epistaxis (nosebleeds). This study found a higher prevalence of blood group O in Caucasian patients admitted for nosebleeds compared to controls.
Area of Science:
- Hematology
- Genetics
- Epidemiology
Background:
- Blood group O is linked to lower von Willebrand factor expression, suggesting a potential bleeding tendency.
- Lower epistaxis (nosebleed) admission rates in Asians versus Caucasians may be due to higher O blood group prevalence in Caucasians.
Purpose of the Study:
- To investigate if blood group O is over-represented in Caucasian patients admitted with epistaxis.
- To determine if blood group O is a risk factor for epistaxis.
Main Methods:
- Retrospective study of Caucasian patients admitted with epistaxis (2000-2005).
- Control groups included patients undergoing total hip arthroplasty and those giving birth.
- Data sourced from computerized hospital in-patient and blood bank databases.
Main Results:
- 1261 Caucasian patients admitted with epistaxis were identified.
- Blood group O was present in 50.44% of epistaxis patients.
- Blood group O was present in 45.10% of the control group (p = 0.008).
Conclusions:
- Blood group O appears to be over-represented in Caucasian patients admitted with epistaxis.
- This finding suggests that blood group O may be a risk factor for epistaxis.
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